Japan, year 1891. In the city of Shimizu in the providence of Mino live the Apricot family dedicated to medicine. With no male heirs, Tooru has decided to teach his eldest granddaughter, Sachie, his knowledge of traditional medicine, Kampo. The problem? Sachie is already 23 years old, and her father is still looking for a way to marry her off to a prominent family, something Sachie will refuse.